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-synuclein, which can be a most important element of Lewy bodies, in PARK one in 1997 and parkin in PARK 2 in 1998, that's an E3 ubiquitin ligase and leads to endoplasmic reticulum (ER) strain, counsel that dysfunction on the intracellular proteinase devices, such as ubiquitin-proteasome program or lysosomal technique, which removes unneeded toxic

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